Purine metabolism in the reperfused porcine myocardium
نویسندگان
چکیده
منابع مشابه
Binding Protein in Ischemic and Reperfused Myocardium
In this study, fatty acid binding protein was used to protect an ischemic heart from reperfusion injury. Isolated rat heart was preperfused in the presence of 1.4 ,uM liposome-bound fatty acid binding protein for 15 minutes, followed by 30 minutes of ischemia and 30 minutes of reperfusion. Our results indicated better preservation of myocardial high-energy phosphate compounds (including ATP and...
متن کاملChanges in substrate metabolism and effects of excess fatty acids in reperfused myocardium.
The purpose of these studies was to characterize the rates of fatty acid oxidation in reperfused myocardium and test the influence of excess fatty acids (FA) on mechanical function in the extracorporeally perfused, working swine heart model. Seventeen animals were prepared. Eight were untreated (LOW FA group; serum FA averaged 0.55 +/- 0.07 mumol/ml) and nine received a constant infusion of 10%...
متن کاملGlucose metabolism in reperfused myocardium measured by [2-18F] 2-fluorodeoxyglucose and PET.
OBJECTIVE [2-18F] 2-fluorodeoxyglucose (FDG) is widely used to trace glucose metabolism for cardiac imaging with positron emission tomography. Because the transport and phosphorylation rates differ for glucose and FDG, a lumped constant (LC) is used to correct for these differences. The effects of ischemia and reperfusion on the LC in vivo are unknown. To determine the validity of FDG as a trac...
متن کاملPoly(ADP-ribose) polymerase activation in the reperfused myocardium.
The activation of poly(ADP-ribose) polymerase (PARP) is now considered a final common effector in various types of tissue injury including systemic inflammation, circulatory shock and ischemia/reperfusion. Free radical and oxidant production and related cytotoxicity during ischemia/reperfusion leads to DNA strand breakage which activates the nuclear enzyme PARP and initiates an energy-consuming...
متن کاملSimvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts.
BACKGROUND Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in cardiac contractile dysfunction as well as cardiomyocyte injury. These deleterious effects are due in large part to endothelial dysfunction leading to the upregulation of cell adhesion molecules and subsequent neutrophil-endothelium interaction. At clinically relevant doses, simvastatin...
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ژورنال
عنوان ژورنال: Acta Physiologica Scandinavica
سال: 2005
ISSN: 0001-6772,1365-201X
DOI: 10.1111/j.1365-201x.2005.01476_1.x